TPP1 Rabbit Polyclonal Antibody

CAT#: TA308202

Rabbit polyclonal antibody to CLN2 (tripeptidyl peptidase I)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 7.5% SDS PAGE. CLN2 antibody. TA308202 diluted at 1:1000.

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  TPP1 antibody detects TPP1 protein at cytosol on normal liver by immunohistochemical analysis. Sample: Paraffin-embedded normal liver. TPP1 antibody (TA308202) dilution: 1:500.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Chimpanzee)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 224 and 563 of CLN2 (Uniprot ID#O14773)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 61 kDa
• Gene Name: tripeptidyl peptidase 1
• Database Link:
  NP_000382
  Entrez Gene 1200 Human
  UniProt ID O14773
• Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq]
• Synonyms: CLN2; GIG1; LPIC; SCAR7; TPP-1
• Note: Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

• Protein Families: Protease
• Protein Pathways: Lysosome