Thrombomodulin (THBD) Rabbit Polyclonal Antibody

CAT#: TA308080

Rabbit Polyclonal antibody to Thrombomodulin (thrombomodulin)

Product Images

Sample (30 ug of whole cell lysate). A: THP-1. 7.5% SDS PAGE. TA308080 diluted at 1:500.

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  Thrombomodulin antibody [C3], C-term detects THBD protein at cytosol and membrane on gastric carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded gastric carcinoma. Thrombomodulin antibody [C3], C-term (TA308080) dilution: 1:500.

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  Immunofluorescence analysis of paraformaldehyde-fixed A549, using Thrombomodulin (CD141) (TA308080) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 512 and 575 of Thrombomodulin (Uniprot ID#P07204)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: thrombomodulin
• Database Link:
  NP_000352
  Entrez Gene 7056 Human
  UniProt ID P07204
• Background: The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq]
• Synonyms: AHUS6; BDCA3; CD141; THPH12; THRM; TM

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades