CBS Rabbit Polyclonal Antibody
$665.00
2 Weeks*
Specifications
| Product Data | |
| Application | IF, IHC, IP, WB |
|---|---|
| Recommended Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000 |
| Reactivity | Bovine, Human (Predicted: Mouse, Rabbit, Rat, X. tropicalis) |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 39 and 251 of CBS (Uniprot ID#P35520) |
| Buffer | 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
| Purification | Purified by antigen-affinity chromatography. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 61 kDa |
| Gene Name | cystathionine-beta-synthase |
| Database Link | |
| Background | The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. provided by RefSeq |
| Synonyms | HIP4 |
| Note | Seq homology of immunogen across species: Mouse (94%), Rabbit (95%), Rat (94%), Bovine (94%), Xenopus tropicalis (93%) |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Cysteine and methionine metabolism, Glycine, Metabolic pathways, Selenoamino acid metabolism, serine and threonine metabolism |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer
Kim, Ju, Yoo et al
Cell Rep Med (2023) 4 (10), 101224 DOI: 10.1016/j.xcrm.2023.101224
Kim, Ju, Yoo et al
Cell Rep Med (2023) 4 (10), 101224 DOI: 10.1016/j.xcrm.2023.101224
Cited by 23
AI Summary: OriGene’s CBS antibody (Cat# TA308071) was used in this study to investigate the role of glutathione pathway proteins in predicting and understanding chemotherapy response in bladder cancer.
Snippet: ANPEP (CD13) Santa cruz Cat# sc-13536;RRID:AB_626894 BDNF Invitrogen Cat# PA5-95183;RRID:AB_2806988 BICDL1 (CCDC64) Invitrogen Cat# PA5-66367;RRID:AB_2663774 CBS Origene Cat# TA308071;RRID: NA CD11c NOVUS Cat# NBP2-44599;RRID: NA CD247 (CD3-zeta) Santa cruz Cat# sc-1239;RRID:AB_627020 CD44v6 Abcam Cat# ab78960;RRID:AB_1603730 CDK1 A
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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