FGFRL1 Rabbit Polyclonal Antibody
$665.00
5 Days*
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000 |
| Reactivity | Human (Predicted: Mouse, Rat) |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant fragment contain a sequence corresponding to a region within amino acids 150 and 476 of FGFR5 (Uniprot ID#Q8N441) |
| Buffer | 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
| Concentration | lot specific |
| Purification | Purified by antigen-affinity chromatography. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 55 kDa |
| Gene Name | fibroblast growth factor receptor-like 1 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. provided by RefSeq |
| Synonyms | FGFR5; FHFR |
| Note | Seq homology of immunogen across species: Mouse (88%), Rat (89%) |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD
Wang, Chen, Hu et al
FASEB J (2023) 37 (2), e22773 DOI: 10.1096/fj.202201359R
Wang, Chen, Hu et al
FASEB J (2023) 37 (2), e22773 DOI: 10.1096/fj.202201359R
AI Summary: OriGene’s rabbit polyclonal anti-FGFRL1 antibody was used in this study to detect FGFRL1 protein expression, helping to elucidate its role in selective neurodegeneration in Alzheimer’s and Parkinson’s disease models.
Snippet: ouse monoclonal anti-myc antibody 9E10 (1:100, Santa Cruz Biotechnology), rabbit polyclonal anti-FGFRL1 antibody (1:1000, Origene), rabbit monoclonal anti-SDC3 antibody (1:1000, Abcam), and mouse monoclonal anti-β-actin AC-15 antibody (1:5000, Sigma). IRDye 680RD-labeled goat anti-rabbit antibodies (1:2000, LI-COR) and IRDye 800CW-labeled goat anti-mous
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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