NANS Rabbit Polyclonal Antibody

SKU TA307925

Rabbit polyclonal antibody to NANS (N-acetylneuraminic acid synthase)

Product Data

• Application: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivity: Bovine), Chicken, Human (Predicted: Mouse, Pig, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 54 and 359 of NANS (Uniprot ID#Q9NR45)
• Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 40 kDa
• Gene Name: N-acetylneuraminate synthase
• Database Link:
  NP_061819
  Q9NR45
• Background: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq]
• Synonyms: HEL-S-100; SAS
• Note: Seq homology of immunogen across species: Mouse (97%), Chicken (88%), Pig (97%), Rat (97%), Bovine (97%)

Reference Data

• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Metabolic pathways