TCF3 / E2A (TCF3) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | TCF3 antibody was raised against a 17 amino acid peptide near the amino terminus of human TCF3. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | transcription factor 3 |
| Database Link | |
| Background | The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem cells. |
| Synonyms | AGM8; bHLHb21; E2A; E47; ITF1; TCF-3; VDIR |
| Reference Data | |
| Protein Categories | Cancer: Haematopoietic and Lymphoid, Immune system diseases, Intracellular Proteins, Transciption Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Single-base editing of rs12603332 on Chromosome 17q21 with a Cytosine Base Editor regulates ORMDL3 and ATF6α expression
Weng, Miller, Pham et al
Allergy (2021)
Weng, Miller, Pham et al
Allergy (2021)
Cited by 11
AI Summary: In this study, OriGene’s human recombinant E47 protein and E47 antibody (catalog number TA306926) were used to investigate the binding of the E47 transcription factor to the rs12603332-T allele in vitro, helping to elucidate the functional role of this SNP in regulating gene expression.
Snippet: use. Human recombinant E47 protein (a member of the helix-loop-helix family of transcription factors)17,18 and E47 antibody (catalog number TA306926) were purchased from Origene. 50 ng E47 protein was incubated with
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
