PRDM16 Rabbit Polyclonal Antibody

CAT#: TA306900

Rabbit Polyclonal PRDM16 Antibody

Product Images

Western blot analysis of PRDM16 in rat brain tissue lysate with PRDM16 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of PRDM16 in rat brain tissue with PRDM16 antibody at 2.5 ug/mL.

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  Immunofluorescence of PRDM16 in Human Brain cells with PRDM16 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PRDM16.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: PR domain 16
• Database Link:
  NP_071397
  Entrez Gene 70673 MouseEntrez Gene 100366024 RatEntrez Gene 63976 Human
  UniProt ID Q9HAZ2
• Background: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
• Synonyms: CMD1LL; LVNC8; MEL1; PFM13