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RHBDD2 Rabbit Polyclonal Antibody

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SKU
TA306891
Rabbit Polyclonal RHBDD2 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

Frequently Bought Together (2)

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LY421772 Transient overexpression lysate of rhomboid domain containing 2 (RHBDD2), transcript variant 1 (as WB positive control) 100 ug
$436.00

View other "RHBDD2 or NM_001040456" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen RHBDD2 antibody was raised against an 18 amino acid peptide from near the center of human RHBDD2.
Buffer PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name rhomboid domain containing 2
Database Link
Background The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.
Synonyms NPD007; RHBDL7
Reference Data
Protein Categories Enzyme: Peptidases, Membrane Proteins
Protein Families Transmembrane
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Documents
Resources

file-alt Citations

RHBDD2‑WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells
Ferretti, Canzoneri, Palma et al
Oncol Rep (2021) 46 (2) DOI: 10.3892/or.2021.8108
Cited by 4
AI Summary: OriGene’s Rabbit anti‑RHBDD2 antibody (cat. no. TA306891) was used in this study to detect RHBDD2 protein expression and investigate its interaction with WWOX during different stages of breast cell proliferation and differentiation.
Snippet: The primary Abs were as follows: Rabbit anti‑RHBDD2 (cat. no. TA306891;OriGene Technologies, Inc.), rabbit anti‑WWOX (Aldaz Lab) (20),
IP
RHBDD2 overexpression promotes a chemoresistant and invasive phenotype to rectal cancer tumors via modulating UPR and focal adhesion genes
Palma, Raffa, Garcia-Fabiani et al
Biochim Biophys Acta Mol Basis Dis (2020) 1866 (8), 165810 DOI: 10.1016/j.bbadis.2020.165810
Cited by 14
AI Summary: OriGene products, specifically the RHBDD2 cDNA clone (RC221091) and RHBDD2 shRNA (TL313419), were used in this study to manipulate RHBDD2 expression in CACO2 cells, enabling the authors to investigate its role in chemoresistance, cell migration, and gene regulation in rectal cancer.
Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression
Canzoneri, Rabassa, Gurruchaga et al
Oncol Rep (2018) 40 (2), 909-915 DOI: 10.3892/or.2018.6489
Cited by 9
AI Summary: In this study, OriGene products—including the RHBDD2 variant 1 (Cat# RC224591) and variant 2 (Cat# RC224592) expression plasmids and anti-RHBDD2 antibody (Cat# TA323228)—were used to analyze the expression, function, and localization of RHBDD2 splicing variants in breast cancer cells, helping to demonstrate the association between RHBDD2 variant 2 and breast cancer progression.
Spatiotemporal expression of Rhomboid domain containing 2 (Rhbdd2) during rat development
Ferretti, Canzoneri, Barbeito et al
Acta Histochem. (2015)
Cited by 5
AI Summary: OriGene’s anti-human RHBDD2 polyclonal antibody (TA306891) was used for immunohistochemistry to detect and analyze Rhbdd2 protein expression in rat and mouse tissues throughout development in this study.
Snippet: Samples were then incubated overnight with anti-human RHBDD2 polyclonal antibody (TA306891, Origene, USA) (1 μg/ml, dilution 1:150), which cross-reacts with rat and mouse, at 4 °C, whereas negative controls were incubated with PBS under the same conditions ... Cite SaveSaving
IHC
Rhomboid family gene expression profiling in breast normal tissue and tumor samples
Canzoneri, Lacunza, Isla Larrain et al
Tumour Biol. (2013)
Cited by 46
AI Summary: OriGene’s polyclonal RHBDD2 antibody (TA306891) was used for immunohistochemistry to assess RHBDD2 protein expression in breast tissue and tumor samples in this study.
Snippet: Page 3. 10 min in a microwave oven followed by a 20-min cool down. In order to block nonspecific antibody binding, the slides were incubated with 10 % horse serum in PBS for 30 min. Primary polyclonal RHBDD2 antibody (TA306891, Origene, USA) was diluted 1
IHC
RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer
Lacunza, Canzoneri, Rabassa et al
Tumour Biol. (2012) 33 (6), 2393-9 DOI: 10.1007/s13277-012-0503-3
Cited by 31
AI Summary: OriGene’s anti-RHBDD2 polyclonal antibody (TA306891) was used to detect RHBDD2 protein expression in colorectal tissue samples, supporting the study’s findings on RHBDD2 overexpression in advanced colorectal cancer.
Snippet: RHBDD2 protein was detected using a commercially anti-RHBDD2 polyclon- al antibody (TA306891, Origene, USA) and horseradish peroxidase (HRP)-conjugated antirabbit secondary antibody (Dako, Denmark, 1:2,000) followed by chemiluminescence autoradiography.
IHC
Showing 1-6 of 7 papers.
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