PPAPDC1A (PLPP4) Rabbit Polyclonal Antibody

CAT#: TA306884

Rabbit Polyclonal PPAPDC1A Antibody

Product Images

Western blot analysis of PPAPDC1A in human brain tissue lysate with PPAPDC1A antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of PPAPDC1A in human brain tissue with PPAPDC1A antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PPAPDC1A antibody was raised against a 14 amino acid peptide near the carboxy terminus of human PPAPDC1A.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phospholipid phosphatase 4
• Database Link:
  NP_001025230
  Entrez Gene 309014 RatEntrez Gene 381925 MouseEntrez Gene 196051 Human
  UniProt ID Q5VZY2
• Background: Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.
• Synonyms: DPPL2; PPAPDC1; PPAPDC1A

Reference Data

• Protein Families: Transmembrane