FRMPD2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, ICC: 5 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | FRMPD2 antibody was raised against a 15 amino acid peptide from near the amino terminus of human FRMPD2. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | FERM and PDZ domain containing 2 |
| Database Link | |
| Background | The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion. |
| Synonyms | FERM and PDZ domain containing 2; MGC35285; MGC87776; MGC87777; MGC90186; PDZD5C; PDZ domain containing 5C; PDZK5C |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
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Citations
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors
Lu, Zhang, Wang
Biochem. Biophys. Res. Commun. (2019) 516 (1), 63-67 DOI: 10.1016/j.bbrc.2019.05.087
Lu, Zhang, Wang
Biochem. Biophys. Res. Commun. (2019) 516 (1), 63-67 DOI: 10.1016/j.bbrc.2019.05.087
AI Summary: OriGene’s rabbit anti-Frmpd2 antibody was used in this study to detect Frmpd2 protein, enabling the authors to investigate its interaction with NMDA receptor subunits.
Snippet: The following antibodies were used: Frmpd2 (rabbit, Sigma;rabbit, Origene), GST (rabbit, Invitrogen), GFP (rabbit, Invitrogen), GluN2A (rabbit, Proteintech), GluN2B(mouse, Proteintech;rabbit, Abcam), GluN1 (rabbit, Abcam), PSD-95 (guinea pig, SYSY;mouse, Millipore
Showing 1-1 of 1 papers.
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