INSM1 Rabbit Polyclonal Antibody

CAT#: TA306849

Rabbit Polyclonal IA-1 Antibody

Product Images

Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: INSM transcriptional repressor 1
• Database Link:
  NP_002187
  Entrez Gene 53626 MouseEntrez Gene 100912563 RatEntrez Gene 3642 Human
  UniProt ID Q01101
• Background: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
• Synonyms: IA-1; IA1