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SKA3 Rabbit Polyclonal Antibody

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SKU
TA306845
Rabbit Polyclonal SKA3 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
5 Days*
Bulk/Customize

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Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 0.5 - 1 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SKA3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human SKA3.
Buffer PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name spindle and kinetochore associated complex subunit 3
Database Link
Background Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
Synonyms C13orf3; RAMA1
Reference Data
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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