RIP (RIPK1) Rabbit Polyclonal Antibody

CAT#: TA306838

Rabbit Polyclonal RIPK1 Antibody

Product Images

Western blot analysis of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 ug/ml.

• 

  Immunohistochemistry of RIPK1 in mouse kidney tissue with RIPK1 antibody at 2.5 ug/ml.

• 

  Immunofluorescence of RIPK1 in Mouse Kidney cells with RIPK1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RIPK1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: receptor interacting serine/threonine kinase 1
• Database Link:
  NP_003795
  Entrez Gene 19766 MouseEntrez Gene 306886 RatEntrez Gene 8737 Human
  UniProt ID Q13546
• Background: RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIPK1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
• Synonyms: RIP; RIP-1; RIP1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway