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JMJD1C Rabbit Polyclonal Antibody

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SKU
TA306830
Rabbit Polyclonal JMJD1C Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
3 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen JMJD1C antibody was raised against a 20 amino acid peptide from near the amino terminus of human JMJD1C.
Buffer PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name jumonji domain containing 1C
Database Link
Background The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist. This antibody will not cross-react with JMJD1A or JMJD1B.
Synonyms RP11-10C13.2; TRIP8
Reference Data
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
Viscarra, Wang, Nguyen et al
Nat Commun (2020) 11 (1), 796 DOI: 10.1038/s41467-020-14617-1
Cited by 75
AI Summary: OriGene contributed to this study by providing the full-length human JMJD1C plasmid, which was used to investigate the role of JMJD1C in lipogenic gene transcription.
Snippet: H3K9me2 (ab176882, 2 µg/µg of chromatin), H3K9me3 (ab8898, 2 µg/µg of chromatin), and H3K4me3 (ab8580, 2 µg/µg of chromatin) from Abcam. Full-length human JMJD1C plasmid was obtained from OriGene. HepG2 and 293FT cells were obtained from ATCC. Cells were grown in Dulbecco's modified Eagle medium (DMEM) supplemented with 10% fetal bovine serum and 100 units/mL of penicillin and strep
FigureFigureFigure
ChIP
Showing 1-1 of 1 papers.
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