Tnfaip3 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | TNFAIP3 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TNFAIP3. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | tumor necrosis factor, alpha-induced protein 3 |
| Database Link | |
| Background | TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist. |
| Synonyms | A20; OTUD7C; TNFA1P2 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, Cancer: Haematopoietic and Lymphoid, Cytokines, Enzyme: Peptidases, Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
The Effects of Interleukin-17 (IL-17)-Related Inflammatory Cytokines and A20 Regulatory Proteins on Astrocytes in Spinal Cord Cultured In Vitro
Zong, Li, Zeng et al
Cell. Physiol. Biochem. (2016) 38 (3), 1100-10 DOI: 10.1159/000443060
Zong, Li, Zeng et al
Cell. Physiol. Biochem. (2016) 38 (3), 1100-10 DOI: 10.1159/000443060
Cited by 8
AI Summary: In this study, OriGene products—specifically the A20 (TNFAIP3) antibody and p-NF-κB/p65 (Ser536) antibody—were used to detect and analyze the expression of key regulatory proteins involved in inflammatory responses in mouse astrocytes following IL-17 stimulation.
Snippet: A20 (TNFAIP3) antibody and p-NF-κB/p65 (Ser536) antibody were purchased from Origene (OriGene Technologies, Inc., USA);GAPDH rabbit polyclonal antibody was purchased from Bioss, Inc. (China). Isolating and culturing mouse astrocytes. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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