CDC42 Chicken Polyclonal Antibody
Chicken Polyclonal CDC42 Antibody
Product Datasheet for 'TA306749'
|Recommend Dilution||WB: 0.5 - 1 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||CDC42 antibody was raised against a 17 amino acid peptide near the amino terminus of human CDC42.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||cell division cycle 42|
|Background||CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to S. cerevisiae CDC42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. CDC42 is thought to regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. At least two isoforms of CDC42 are known to exist.|
|Synonyms||CDC42Hs; G25K; TKS|
|Protein Families||Druggable Genome|
|Protein Pathways||Adherens junction, Axon guidance, Chemokine signaling pathway, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Fc gamma R-mediated phagocytosis, Focal adhesion, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Tight junction, VEGF signaling pathway|
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