LRFN2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | LRFN2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human LRFN2. The immunogen is located within amino acids 700 - 750 of LRFN2. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | leucine rich repeat and fibronectin type III domain containing 2 |
| Database Link | |
| Background | LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN2 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family. |
| Synonyms | FIGLER2; KIAA1246; SALM1 |
| Reference Data | |
| Protein Categories | Membrane Proteins |
| Protein Families | Transmembrane |
Reviews
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Citations
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition
Yu, Hu, Fu et al
J Immunother Cancer (2023) 11 (10) DOI: 10.1136/jitc-2023-007230
Yu, Hu, Fu et al
J Immunother Cancer (2023) 11 (10) DOI: 10.1136/jitc-2023-007230
Cited by 27
AI Summary: In this study, the anti-LRFN2 antibody (Cat: TA306739, OriGene, USA) from OriGene was used to detect LRFN2 protein expression, helping to elucidate its role in bladder cancer immunotherapy resistance.
Snippet: transferred PVDF (Polyvinylidene fluoride) membranes. The signals were captured using a Western Blot Substrate Kit (Tanon, Shanghai, China). The primary antibodies included anti-LRFN2 (Cat: TA306739, OriGene, USA), anti-GAPDH (Cat: ab8245, Abcam, USA), anti-Ikkα+β antibody (Cat: ET1611-23, HUABIO, China), anti-p65 (Cat: ER0815, HUABIO, China), anti-p-p65 (Cat: ET1604-27, HUABIO, China), anti-IKB
Showing 1-1 of 1 papers.
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