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TREX1 Rabbit Polyclonal Antibody

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SKU
TA306702
Rabbit Polyclonal TREX1 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

Frequently Bought Together (2)

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View other "TREX1 or NM_016381" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 0.5 and 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen TREX1 antibody was raised against a 15 amino acid peptide near the center of human TREX1.
Buffer PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name three prime repair exonuclease 1
Database Link
Background Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. TREX1 antibody will not cross-react with the related protein TREX2.
Synonyms AGS1; CRV; DRN3; HERNS
Reference Data
Protein Categories Allergies and autoimmune diseases, Membrane Proteins, Nervous system Diseases
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytosolic DNA-sensing pathway
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Documents
Resources

file-alt Citations

Phenotypic Variation in Aicardi-Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release
Cuadrado, Michailidou, van Bodegraven et al
J. Immunol. (2015)
Cited by 49
AI Summary: In this study, OriGene's rabbit anti-RNASEH2A antibody (TA306706) was used to detect RNASEH2A protein levels by immunoblotting, enabling the authors to assess the effects of gene silencing on protein expression in their investigation of Aicardi-Goutières syndrome.
Snippet: Blots were blocked in SuperMix (0.606% Tris, 0.9% NaCl, 0.25% gelatin [pH 7.4]) and incubated overnight with primary Abs: rabbit anti-TREX1 (1:300, Rab34, a gift of Dr. Tomas Lindahl), rabbit anti-RNASEH2A (1:2000, Origene, Rockville, MD, TA306706), mouse anti ... Cite SaveSaving
WB
Showing 1-1 of 1 papers.
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