VGF Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | VGF antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human VGF. The immunogen is located within the last 50 amino acids of VGF. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | VGF nerve growth factor inducible |
| Database Link | |
| Background | VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments. |
| Synonyms | SCG7; SgVII |
| Reference Data | |
| Protein Categories | Growth Factors, Secreated Proteins |
| Protein Families | Secreted Protein |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
MT2, a NGF-mimetic compound, decreases myocardial damage induced by ischemia/reperfusion injury
Castronovo
Thesis (2015)
Castronovo
Thesis (2015)
Snippet: Page 17. 17 Danvers, MA, USA), anti-MKP1 (Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-VGF (OriGene, Rockville, MD, USA) and mouse anti β-actin (Santa Cruz Biotec- nology);all the antibodies were used at 1:1000, final dilution. HRP-coniugated anti- ... Cite SaveSaving
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