UNC93B (UNC93B1) Rabbit Polyclonal Antibody

CAT#: TA306557

Rabbit Polyclonal Unc93b Antibody

Product Images

Western blot analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of Unc93b in human heart with Unc93b antibody at 2.5 ug/ml.

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  Immunofluorescence of Unc93b in Human Heart cells with Unc93b antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Unc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: unc-93 homolog B1 (C. elegans)
• Database Link:
  AAH33623
  Entrez Gene 81622 Human
  UniProt ID Q9H1C4
• Background: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.
• Synonyms: IIAE1; Unc-93B1; UNC93; UNC93B