AIFM3 Rabbit Polyclonal Antibody

CAT#: TA306551

Rabbit Polyclonal AIFM3 Antibody

Product Images

Western blot analysis of AIFM3 in human brain tissue lysate with AIFM3 antibody at (A) 1 and (B) 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: AIFM3 antibody was raised against a 16 amino acid peptide from near the center of human AIFM3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: apoptosis inducing factor, mitochondria associated 3
• Database Link:
  NP_001018070
  Entrez Gene 72168 MouseEntrez Gene 303786 RatEntrez Gene 150209 Human
  UniProt ID Q96NN9
• Background: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
• Synonyms: AIFL

Reference Data

• Protein Families: Druggable Genome