NIPSNAP1 Rabbit Polyclonal Antibody

CAT#: TA306549

Rabbit Polyclonal NIPSNAP Antibody

Product Images

Western blot analysis of NIPSNAP in human brain tissue lysate with NIPSNAP antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemical staining of human brain tissue using Nipsnap antibody at 2.5 ug/ml.

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  Immunofluorescence of nipsnap in human brain tissue with nipsnap antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NIPSNAP antibody was raised against a 19 amino acid peptide from near the center of human NIPSNAP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nipsnap homolog 1 (C. elegans)
• Database Link:
  NP_003625
  Entrez Gene 18082 MouseEntrez Gene 360971 RatEntrez Gene 8508 Human
  UniProt ID Q9BPW8
• Background: NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP’s expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.
• Synonyms: C. elegans; NIPSNAP