SLPI Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, ICC: 10 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | SLPI antibody was raised against a 17 amino acid peptide from near the center of human SLPI. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | secretory leukocyte peptidase inhibitor |
| Database Link | |
| Background | Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway. |
| Synonyms | ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4 |
| Reference Data | |
| Protein Categories | Secreated Proteins |
| Protein Families | Secreted Protein |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Increased Secretory Leukocyte Protease Inhibitor (SLPI) Production by Highly Metastatic Mouse Breast Cancer Cells
Sayers, Brooks, Sayers et al
PLoS ONE (2014) 9 (8), e104223 DOI: 10.1371/journal.pone.0104223
Sayers, Brooks, Sayers et al
PLoS ONE (2014) 9 (8), e104223 DOI: 10.1371/journal.pone.0104223
Cited by 15
AI Summary: OriGene's rabbit polyclonal secretory leukocyte peptidase inhibitor (SLPI) antibody was used for immunohistochemical staining to detect SLPI protein levels in breast tumor samples, aiding in the study's investigation of SLPI's role in cancer metastasis.
Snippet: Following a 5% normal-goat-serum block, secretory leukocyte peptidase inhibitor antibody (SLPI;1:7500, rabbit polyclonal, Origene) was applied overnight at 4°C. Biotinylated secondary goat anti-rabbit, then Vector's Elite Standard ABC kit were utilized with detection ... Cite SaveSaving
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