BUB1 Rabbit Polyclonal Antibody
Frequently bought together (3)
Transient overexpression lysate of budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1)
USD 436.00
Recombinant protein of human budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1), 20 µg
USD 867.00
Other products for "BUB1"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | WB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Bub1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human Bub1. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | BUB1 mitotic checkpoint serine/threonine kinase |
Database Link | |
Background | Bub1 was initially identified as the mammalian homolog to the yeast protein through a cDNA screen. Bub1 encodes a kinase involved in the formation of the spindle checkpoint, an important mechanism that ensures high fidelity mitotic chromosome segregation. It is thought to be required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshim protein and metaphase congression. Bub1 functions by phosphorylating cdc20, a member of the mitotic checkpoint complex and activating the spindle checkpoint. A related protein kinase Bub3 interacts with Bub1 and targets it to kinetochores prior to chromosome alignment. Mutations in bub1 have been associated with aneuploidy and several forms of cancer. |
Synonyms | BUB1A; BUB1L; hBUB1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation |
Documents
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