BUB3 Rabbit Polyclonal Antibody

CAT#: TA306431

Rabbit Polyclonal Bub3 Antibody


USD 528.00

5 Days*

Size
    • 100 ug

Product Images

Frequently bought together (3)
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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 0.5 - 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Bub3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human bub3.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name BUB3, mitotic checkpoint protein
Background The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
Synonyms BUB3L; hBUB3
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.