DARC (ACKR1) Rabbit Polyclonal Antibody

CAT#: TA306405

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Rabbit Polyclonal DARC Antibody


 Product Datasheet for 'TA306405'

USD 415.00


Availability*
5 Days

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name atypical chemokine receptor 1 (Duffy blood group)
Background DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Synonyms CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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