TRPC6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 0.5 - 1 ug/mL, ICC: 10 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | TRPC6 antibody was raised against a 14 amino acid peptide from near the amino terminus of human TRPC6. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | transient receptor potential cation channel subfamily C member 6 |
| Database Link | |
| Background | The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types.. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. |
| Synonyms | FSGS2; TRP6 |
| Reference Data | |
| Protein Categories | Membrane Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells
Wajdner, Farrington, Barnard et al
Physiol Rep (2017) 5 (5) DOI: 10.14814/phy2.13166
Wajdner, Farrington, Barnard et al
Physiol Rep (2017) 5 (5) DOI: 10.14814/phy2.13166
AI Summary: OriGene’s TRPC6 antibody (TA306349) was used for immunostaining to detect TRPC6 expression in human mast cells, contributing to the characterization of calcium channel involvement in FcεRI-mediated signaling.
Snippet: Blocking solution of 0.02% Triton‐X‐100 and 0.2% fish skin gelatin (Sigma) was applied for at least 2 h at room temperature before addition of primary antibody overnight at 4°C (TRPC1, Alomone ACC‐010;TRPC6, Origene TA306349
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
