Caspase 2 (CASP2) Rabbit Polyclonal Antibody

CAT#: TA306194

Rabbit Polyclonal Caspase-2 Antibody

Product Images

Western blot analysis of caspase-2 in Ramos cells with caspase-2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.

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  Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Caspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caspase 2
• Database Link:
  NP_001215
  Entrez Gene 12366 MouseEntrez Gene 835 Human
  UniProt ID P42575
• Background: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).
• Synonyms: CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57

Reference Data

• Protein Families: Druggable Genome, Protease