TAB1 Rabbit Polyclonal Antibody

CAT#: TA306187

Rabbit Polyclonal TAB1 Antibody

Antibody Service


 Product Datasheet for 'TA306187'

USD 371.00


Availability*
2 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IF
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 1 ug/mL, IF: 2 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name TGF-beta activated kinase 1/MAP3K7 binding protein 1
Background TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1 (6).
Synonyms 3'-Tab1|MAP3K7IP1
Reference Data
Protein Families Druggable Genome
Protein Pathways MAPK signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.