cIAP1(BIRC2) Rabbit Polyclonal Antibody

CAT#: TA306169

Rabbit Polyclonal cIAP Antibody

Antibody Service

 Product Datasheet for 'TA306169'

USD 371.00

5 Days

    • 100 ug

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Product Data
Applications WB, IHC, IF
Recommend Dilution WB: 1 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen c-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name baculoviral IAP repeat containing 2
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, (2,3). The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor (2,4). Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP (5). Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP (6).
Synonyms API1|HIAP2|Hiap-2|MIHB|RNF48|c-IAP1|cIAP1
Reference Data
Protein Families Druggable Genome
Protein Pathways Ubiquitin mediated proteolysis, Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.