TICAM2 Rabbit Polyclonal Antibody

CAT#: TA306163

Rabbit Polyclonal TIRP Antibody

Product Images

Western blot analysis of TIRP in human (A), mouse (B), and rat (C) kidney cell lysates with TIRP antibody (C2) at 1 ug/ml.

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  Immunohistochemical staining of Daudi cells using SARM antibody at 2 ug/ml.

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  Immunofluorescence of TIRP in Mouse Kidney cells with TIRP antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TIRP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human TIRP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor adaptor molecule 2
• Database Link:
  AAP81748
  Entrez Gene 353376 Human
  UniProt ID Q86XR7
• Background: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).
• Synonyms: MyD88-4; TICAM-2; TIRAP3; TIRP; TRAM