MD2 (LY96) Rabbit Polyclonal Antibody
Rabbit Polyclonal MD-2 Antibody
Product Datasheet for 'TA306161'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||MD-2 antibody was raised against a peptide corresponding to 13 amino acids near the center of human MD-2. The immunogen is located within the last 50 amino acids of MD-2.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Ion exchange chromatography purified|
|Gene Name||lymphocyte antigen 96|
|Background||MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).|
|Synonyms||ESOP-1; ly-96; MD-2; MD2|
|Protein Families||Secreted Protein|
|Protein Pathways||Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.