BCL2L10 Rabbit Polyclonal Antibody

CAT#: TA306134

Rabbit Polyclonal Bcl-B Antibody

Product images

Western blot analysis of Bcl-B in Jurkat lysate with Bcl-B antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.

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  Immunocytochemistry of Bcl-B in Jurkat cells with Bcl-B antibody at 10 ug/mL.

Specifications

Product Data

• Applications: WB, IF
• Recommend Dilution: WB: 1 ug/mL, ICC: 10 ug/mL
• Reactivity: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Bcl-B antibody was raised against a 16 amino acid peptide from near the amino terminus of human Bcl-B.
• Isotype: IgG
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Gene Name: BCL2 like 10
• Database Link:
  NP_065129
  Entrez Gene 10017 Human
• Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications.
• Synonyms: BCL-B|Boo|Diva|bcl2-L-10

Reference Data

• Protein Families: Transmembrane, Druggable Genome