BCL2L10 Rabbit Polyclonal Antibody
Specifications
Product Data | |
Applications | WB, IF |
Recommend Dilution | WB: 1 ug/mL, ICC: 10 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Bcl-B antibody was raised against a 16 amino acid peptide from near the amino terminus of human Bcl-B. |
Isotype | IgG |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Gene Name | BCL2 like 10 |
Database Link | |
Background | Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications. |
Synonyms | BCL-B|Boo|Diva|bcl2-L-10 |
Reference Data | |
Protein Families | Transmembrane, Druggable Genome |
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