PHAP1 (ANP32A) Rabbit Polyclonal Antibody

SKU TA306130

Rabbit Polyclonal PHAP I Antibody

Product Data

• Application: ELISA, IF, IHC, WB
• Recommended Dilution: WB: 1 µg/mL; IHC: 2 µg/mL; IF: 20 µg/mL.; Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in mouse samples; Immunofluorescence in mouse samples. All other applications and species not yet tested.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PHAP I antibody was raised with a synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.
• Specificity: This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PHAP I Antibody is DEAE purified.
• Conjugation: Unconjugated
• Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: acidic nuclear phosphoprotein 32 family member A
• Database Link:
  NP_006296
  P39687
• Background: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
• Synonyms: C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency