AICDA Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB: 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human AID. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | activation-induced cytidine deaminase |
| Database Link | |
| Background | Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5). |
| Synonyms | AID; ARP2; CDA2; HEL-S-284; HIGM2 |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura
Milillo, Molinario, Costanzi et al
J. Nephrol. (2018)
Milillo, Molinario, Costanzi et al
J. Nephrol. (2018)
AI Summary: OriGene contributed to this study by providing the anti-BCL2 antibody, which was used to assess BCL2 protein expression levels as part of the molecular analysis of the MAPK/ERK pathway in IgA nephropathy and Henoch-Schönlein purpura patients.
Snippet: and quanti- fied with Image J. In this study, the following primary antibodies were used: anti-human IgA (Novus Biological, 1:5000), anti- human ERK1/2 (Cell Signalling 1:1000), anti-human phospho ERK1/2 (Pierce 1:1000, Cell Signalling 1:2000), anti-BCL2 (Origene
Showing 1-1 of 1 papers.
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