AICDA Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB: 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human AID. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | activation-induced cytidine deaminase |
| Database Link | |
| Background | Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5). |
| Synonyms | AID; ARP2; CDA2; HEL-S-284; HIGM2 |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins |
Reviews
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