MCG10 (PCBP4) Rabbit Polyclonal Antibody

SKU TA306079

Rabbit Polyclonal MCG10 Antibody

Product Data

• Application: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 1 ug/mL, IF: 20 ug/mL
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MCG10 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MCG10.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: poly(rC) binding protein 4
• Database Link:
  NP_001167571
  P57723
• Background: MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
• Synonyms: CBP; LIP4; MCG10

Reference Data