AVEN Rabbit Polyclonal Antibody

CAT#: TA306070

Rabbit Polyclonal Aven Antibody

Product Images

Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.

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  mmunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/ml.

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  Immunofluorescence of AVEN in Human Spleen cells with AVEN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Aven antibody was raised against a 18 amino acid peptide from near the amino terminus of human Aven.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: apoptosis and caspase activation inhibitor
• Database Link:
  NP_065104
  Entrez Gene 74268 MouseEntrez Gene 311299 RatEntrez Gene 57099 Human
  UniProt ID Q9NQS1
• Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.
• Synonyms: PDCD12