AVEN Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Aven antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Aven. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | apoptosis and caspase activation inhibitor |
| Database Link | |
| Background | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. |
| Synonyms | PDCD12 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
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| FAQs |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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