BACE1 Rabbit Polyclonal Antibody

SKU TA306033

Rabbit Polyclonal BACE Antibody

Product Data

• Application: ELISA, ICC, IF, IHC, WB
• Recommended Dilution: WB: 1 µg/mL; IHC-P: 2.5 µg/mL; ICC: 10 µg/mL; IF: 20 µg/mL.; Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry, Immunocytochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BACE antibody was raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
• Buffer: PBS containing 0.02% sodium azide.
• Purification: BACE Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: beta-secretase 1
• Database Link:
  AF190725
  P56817
• Background: Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
• Synonyms: ASP2; BACE; HSPC104

Reference Data