BACE2 Rabbit Polyclonal Antibody
Rabbit Polyclonal BACE2 Antibody
Product Datasheet for 'TA306032'
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|Recommend Dilution||WB: 1 ug/mL, ICC: 2 ug/mL|
|Immunogen||BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||beta-site APP-cleaving enzyme 2|
|Background||Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the β-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought β-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)|
|Protein Families||Transmembrane, Protease, Druggable Genome|
|Protein Pathways||Alzheimer's disease|