RIP2 (RIPK2) Rabbit Polyclonal Antibody

CAT#: TA306013

Rabbit Polyclonal RICK Antibody


USD 570.00

5 Days*

Size
    • 100 ug

Product Images

Frequently bought together (3)
Transient overexpression lysate of receptor-interacting serine-threonine kinase 2 (RIPK2)
    • 100 ug

USD 436.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 200.00


Recombinant protein of human receptor-interacting serine-threonine kinase 2 (RIPK2), 20 µg
    • 20 ug

USD 867.00

Other products for "RIP2"

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen RICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin .
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name receptor interacting serine/threonine kinase 2
Background Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).
Synonyms CARD3; CARDIAK; CCK; GIG30; RICK; RIP2
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Neurotrophin signaling pathway, NOD-like receptor signaling pathway

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.