CIDE A (CIDEA) Rabbit Polyclonal Antibody

CAT#: TA305986

Rabbit Polyclonal CIDE-A Antibody

Product Images

Western blot analysis of CIDE-A in human brain tissue lysate in the absence (A) or presence (B) of peptide (2085P) with CIDE-A antibody at 1:2000 dilution.

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  Immunohistochemistry of CIDE-A in human brain tissue with CIDE-A antibody at 5 ug/ml.

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  Immunofluorescence of CIDE-A in Human Brain cells with CIDE-A antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 2 ug/mL, IHC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CIDE-A antibody was raised against a peptide corresponding to amino acids 200 to 217 of human CIDE-A.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cell death-inducing DFFA-like effector a
• Database Link:
  AF041378
  Entrez Gene 1149 Human
  UniProt ID O60543
• Background: Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD (1-4). DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified (5). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (5,6). Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.
• Synonyms: CIDE-A