BCL2L2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB:1/1000, IHC-P:1/50-200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-59 amino acids from human Bcl. |
| Specificity | This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-59 amino acids from human Bcl. |
| Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 20.7 kDa |
| Gene Name | BCL2 like 2 |
| Database Link | |
| Background | Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. |
| Synonyms | BCL-W; BCL2-L-2; BCLW; PPP1R51 |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
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Citations
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Swarup, Hinz, Rexach et al
Nat. Med. (2018) 25 (1), 152-164 DOI: 10.1038/s41591-018-0223-3
Swarup, Hinz, Rexach et al
Nat. Med. (2018) 25 (1), 152-164 DOI: 10.1038/s41591-018-0223-3
AI Summary: OriGene’s BCL2L2 antibody was used in this study to detect BCL2L2 protein levels by Western blot, contributing to the analysis of molecular pathways involved in neurodegenerative dementia.
Snippet: Thermo Fisher Scientific);β-actin (1:2,000;Sigma-Aldrich);BCL2L2 (1:1,000;OriGene). Mouse brain samples were dissected, washed in PBS and snap-frozen in liquid nitrogen. Samples were homogenized in 0.5% sarkosyl buffer, and sarkosyl-soluble and sarkosyl-insoluble fractions were separated. …
Showing 1-1 of 1 papers.
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