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NANOG Rabbit Polyclonal Antibody

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SKU
TA302153
NANOG Antibody (N-term)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
5 Days*
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View other "NANOG or NM_024865" antibodies

Specifications
Specifications
Product Data
Application FC, IF, IHC, WB
Recommended Dilution WB:1/1000, IHC-P:1/50-200, IF:1/10-50, FC:1/10-50
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG.
Specificity This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG.
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 34.6 kDa
Gene Name Nanog homeobox
Database Link
Background NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-CGGACGCGCATTANGC-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Synonyms homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog homeobox
Reference Data
Protein Families Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell - Pluripotency
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Documents
Resources

file-alt Citations

CHI3L1 results in poor outcome of ovarian cancer by promoting properties of stem-like cells
Lin, Chiang, Sun et al
Endocr. Relat. Cancer (2018)
AI Summary: In this study, OriGene products contributed by providing the Nanog antibody and siRNAs for SOX2 and CTNNB1 (β-catenin), which were used to investigate the molecular mechanisms underlying CHI3L1's promotion of stem-like properties in ovarian cancer cells.
Snippet: Millipore, Billerica, MA), and probed with Abs specific to α-tubulin (Abcam, 235 Cambridge, UK), β-catenin (Abcam), CHI3L1(R&D Systems), Nanog (OriGene 236 siRNA for SOX2 and CTNNB1 (β-catenin) was designed by and purchased from 293 OriGene Technologies
WB
Showing 1-1 of 1 papers.
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