TRF2 (TERF2) Rabbit Polyclonal Antibody

SKU TA301691

Rabbit Polyclonal Antibody against TRF2

Product Data

• Application: ChIP, Dot, ELISA, FC, ICC/IF, IHC, IP, Simple Western, WB
• Recommended Dilution: Knockdown Validated, Flow Cytometry: 1-5 ug/ml, Dot Blot, Western Blot: 1:2000 - 1:5000, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:200, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, ELISA, Immunoprecipitation: 1:10 - 1:500, Simple Western: 1:25, Immunohistochemistry: 1:200, Immunohistochemistry-Paraffin: 1:200
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Baculovirus purified TRF2 protein.
• Buffer: Tris-glycine, 150mM NaCl, 0.1% BSA. and 0.05% sodium azide
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: telomeric repeat binding factor 2
• Database Link:
  NP_005643
  Q15554
• Background: TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implied a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 may be oncogenic.
• Synonyms: TRBF2; TRF2

Reference Data

• Protein Families: Transcription Factors