DNMT3A Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody against DNMT3a
Product Datasheet for 'TA301633'
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|Applications||WB, IHC, IF|
|Recommend Dilution||WB: 1: 1000|
|Immunogen||This antibody was raised against amino acids 10-118 of the human DNMT3a protein.|
|Gene Name||DNA (cytosine-5-)-methyltransferase 3 alpha|
|Background||Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process.|
|Protein Families||Druggable Genome|
|Protein Pathways||Cysteine and methionine metabolism, Metabolic pathways|