CCR7 (C-term) Rabbit Polyclonal Antibody
Other products for "CCR7"
Specifications
Product Data | |
Applications | IF, IHC |
Recommended Dilution | Immunocytochemistry: 14 µg/ml. Immunohistochemistry on Paraffin Sections: 14 µg/ml. |
Reactivities | Human, Bovine, Bat, Equine, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic 17 amino acid peptide from C-terminus of human CCR7 |
Specificity | Reacts with C-terminus of CCR7 (family: GPCR, subfamily: Chemokine). |
Formulation | PBS containing 0.09% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Peptide Immunogen Affinity Chromatography |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | C-C motif chemokine receptor 7 |
Database Link | |
Background | CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. This receptor is particularly expressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries. |
Synonyms | C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EVI1, BLR2 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.