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GAPDH Rabbit Polyclonal Antibody

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SKU
SP2162P
GAPDH rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $740.00
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View other "GAPDH or NP_002037.2" antibodies

Specifications
Specifications
Product Data
Application IF, WB
Recommended Dilution Western blot: 0.5 - 1 µg/ml, detects a band of approximately 37 kDa in HeLa cell lysates.
Immunocytochemistry.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen A 16 amino acid peptide located near human GAPDH carboxy-terminus
Specificity This antibody recognises an epitope within the C-terminal region (CT) of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Buffer PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0,02% Sodium azide
Concentration lot specific
Purification Affinity chromatography
Conjugation Unconjugated
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name glyceraldehyde-3-phosphate dehydrogenase
Database Link
Background GAPDH is a glycolytic enzyme which plays a key role in energy production, and has also been implicated in numerous cellular processes.
GAPDH is a homotetramer molecule consisting of four 36 kDa subunits, constitutively expressed in most cells and tissues, and is responsible for the generation of energy during carbohydrate metabolism, catalysing the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate.
The role of GAPDH as a multifunctional protein has emerged from many studies, confirming its involvement in critical nuclear pathways, apoptosis, membrane transport and fusion, DNA replication and repair and phosphotransferase activity. Furthermore, the ability of GAPDH to bind with high affinity to ß-amyloid precursor protein (Alzheimer's disease) and selectively with CAG mutated proteins, including huntingtin (Huntingdon's disease) and the androgen receptor (spinobulbar muscular atrophy), has focused many studies towards the role of GAPDH in the pathogenesis of neurodegenerative diseases (1).
Synonyms GAPD, CDABP0047
Reference Data
Protein Categories Cytokines, Intracellular Proteins
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Documents
Resources

file-alt Citations

Characterization of Glomerular Sox9+ Cells in Anti-Glomerular Basement Membrane Nephritis in the Rat
Prochnicki, Amann, Wegner et al
Am J Pathol (2018) 188 (11), 2529-2541 DOI: 10.1016/j.ajpath.2018.07.023
Cited by 11
AI Summary: In this study, OriGene products, specifically the Pax8 antibody (Cat# TA328299) and α-smooth muscle actin antibody (Cat# TA374131), were used for immunofluorescence staining to identify and characterize specific cell populations involved in glomerular injury and repair in a rat model of anti-glomerular basement membrane nephritis.
Cane Toad Skin Extract-Induced Upregulation and Increased Interaction of Serotonin 2A and D2 Receptors via Gq/11 Signaling Pathway in CLU213 Cells
Zulfiker, Hashimi, Good et al
J Cell Biochem (2017) 118 (5), 979-993 DOI: 10.1002/jcb.25627
Cited by 8
AI Summary: In this study, OriGene products—specifically the anti-DRD2 antibody (Cat# TA336660) and anti-HTR2A antibody (Cat# TA326043)—were used to detect and analyze the expression and interaction of serotonin 2A and dopamine D2 receptors in CLU213 cells following treatment with cane toad skin extract.
Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels
Kessler, Reich, Jahn et al
J Gen Virol (2008) 89 (Pt 10), 2427-2436 DOI: 10.1099/vir.0.2008/001610-0
Cited by 19
AI Summary: In this study, OriGene products—including the cathepsin S (CS-S) and cathepsin H (CS-H) antibodies—were used to assess the protein expression levels of key endocytic proteases, helping demonstrate that HCMV infection reduces the expression of these proteases in dendritic cells.
Showing 1-3 of 3 papers.
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