IL1 beta (IL1B) Rabbit Polyclonal Antibody

CAT#: SP2127A

IL1 beta (IL1B) rabbit polyclonal antibody, Azide Free

Specifications

Product Data

• Applications: ELISA, FN, WB
• Recommended Dilution: ELISA.
  Western Blot: Detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1.
  Functional Assays.
• Reactivities: Chicken
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinaint Chicken IL-1B
• Specificity: This antibody recognizes Chicken Interleukin 1 beta (chIL-1beta), which shares homology with Mammalian IL-1 beta. Other species not tested.
  This antibody neutralizes IL-1 beta (Ref.1-2).
• Formulation: PBS
  State: Azide Free
  State: Liquid purified IgG fraction
  Stabilizer: None
  Preservative: None
• Concentration: lot specific
• Purification: Affinity Chromatography on protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 1 beta
• Database Link:
  Entrez Gene 3553 Human
  UniProt ID P01584
• Background: IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.
• Synonyms: IL-1 beta, IL1B, IL1 beta, IL1F2, Catabolin

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus