Eng Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, FC, WB |
|---|---|
| Recommended Dilution | ELISA (1-15 µg/ml). Western blot (1-5 µg/ml). Flow Cytometry (1-20 µg/ml). |
| Reactivity | Mouse |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Highly pure recombinant Mouse soluble CD105 produced in Insect cells. The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis). |
| Specificity | This antibody detects Mouse CD105/Endoglin. Other species not tested. |
| Buffer | PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction |
| Reconstitution Method | Restore with sterile water to a concentration of 0.1-1.0 mg/ml |
| Purification | Protein A Chromatography (+his tag depleted) |
| Conjugation | Unconjugated |
| Storage | Prior to reconstitution store at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | endoglin |
| Database Link | |
| Background | Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells. |
| Synonyms | ENG, END, HHT1, ORW, ORW1 |
| Reference Data | |
| Protein Categories | CD Markers, Growth Factors, Membrane Proteins |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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